Gastrointestinal Disorder Associated with Olmesartan Mimics Autoimmune Enteropathy
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Gastrointestinal Disorder Associated with Olmesartan Mimics Autoimmune Enteropathy
BACKGROUND AND OBJECTIVES Anti-hypertensive treatment with the angiotensin II receptor antagonist olmesartan is a rare cause of severe Sprue-like enteropathy. To substantiate the hypothesis that olmesartan interferes with gut immune homeostasis, clinical, histopathological and immune features were compared in olmesartan-induced-enteropathy (OIE) and in autoimmune enteropathy (AIE). METHODS Me...
متن کاملEnteropathy Associated with Olmesartan
The recognition of an enteropathy caused by olmesartan is recent. It was first described in 2012 by the Mayo Clinic, which presented 22 clinical cases. Olmesartan is a highly prescribed drug and the differential diagnosis of a sprue-like enteropathy is very wide, so it is important to be aware of this pathology. We report a case of a 67-years-old man, with arterial hypertension under treatment ...
متن کاملImmunopathogenesis of olmesartan-associated enteropathy.
BACKGROUND Olmesartan-associated enteropathy (OAE) is characterised by diarrhoea, nausea, vomiting, abdominal pain, weight loss and severe sprue-like enteropathy, all of which are resolved after discontinuation of olmesartan medoximil. AIM To determine the mechanistic similarities of OAE with coeliac sprue. METHODS Duodenal biopsies were extracted from OAE patients before (n = 11) or after ...
متن کاملSevere sprue-like enteropathy associated with olmesartan.
OBJECTIVE To report the response to discontinuation of olmesartan, an angiotensin II receptor antagonist commonly prescribed for treatment of hypertension, in patients with unexplained severe spruelike enteropathy. PATIENTS AND METHODS All 22 patients included in this report were seen at Mayo Clinic in Rochester, Minnesota, between August 1, 2008, and August 1, 2011, for evaluation of unexpla...
متن کاملOlmesartan Enteropathy
Celiac disease is an immune-mediated small intestinal mucosal disorder with characteristic, but nonspecific histopathological changes. A number of heterogeneous disorders may produce similar changes in small bowel biopsies, but these fail to respond to a gluten-free diet. Recently, it has become increasingly appreciated that different medications may cause this sprue-like intestinal disease, in...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2015
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0125024